After being accused of crimes he did not commit, a lonely circus performer exacts his revenge on those who unjustly condemned him. The act sparks something inside of him which he cannot stop and now, years later, his inner-demons have truly surfaced. Part urban legend, part tabloid sensationalism... he is now an unstoppable murderous juggernaut, fueled only by hate.

Penny-less and job-less, Sandy gets by on her looks and attitude, and by borrowing from her high-powered sister. At her best friend's funeral, she meets a handsome con artist, Keith, and as soon as she gets her stolen goods back from him, she plans on being on her own again. But when her sister gets into a load of legal and financial trouble, Sandy accepts a too-good-to-be-true job offer from Keith, and then tries to support her argumentative family.

A simple man, Dr. Walter Newman, has high aspirations to cure all disease through genetic manipulation. His obsession with his mission draws him deeper into his own dark world, distracting him from his wife Olivia and from his responsibilities to his patients at the Edgewood Asylum. The doctors loyal but diabolical nurse, Ms. Tinsley, decides to take matters into her own hands and in secret she conducts her own experiment. When Dr. Newman realizes what has been done, a deformed creature that defies nature is created. Part human, part nightmare. Dr. Newman knows what he must do, but is it already too late?